Senior Scientist / Principal Scientist – Translational Medicine, Oligonucleotide Research
Waltham, MA
Full Time
Genetic Medicines
Experienced
The Company
We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.
Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!
The Team
The Alloy RNA Medicines group is innovating a novel RNA-based drug discovery platform, namely "AntiClastic", spanning the fields of antisense therapeutics to immunomodulating therapeutics. The team works closely with external partners to discover and develop AntiClastic RNA medicines.
The Role
As a Senior Scientist / Principal Scientist – Translational Medicine, you will serve as the translational medicine leader for the Genetic Medicines team at Alloy Therapeutics. In this role, you will drive all aspects of translational medicine for our oligonucleotide drug discovery programs, including design of preclinical pharmacology and toxicology studies. You will bridge rodent and NHP preclinical sciences by integrating DMPK, PK/PD, and biomarker data to build translational results that support candidate selection and advancement. A central focus of this role is leading and expanding Alloy's preclinical study capabilities, from study design through data interpretation. This role requires strong project management capabilities and the ability to operate with a high degree of autonomy in a fast-paced, dynamic start-up environment. Experience in oligonucleotide therapeutics is strongly preferred.
How You'll Drive Impact
Preferred Qualifications
Taking Care of Our PeopleWe support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [email protected]. We will make every effort to respond to your request for disability assistance as soon as possible.
We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.
Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!
The Team
The Alloy RNA Medicines group is innovating a novel RNA-based drug discovery platform, namely "AntiClastic", spanning the fields of antisense therapeutics to immunomodulating therapeutics. The team works closely with external partners to discover and develop AntiClastic RNA medicines.
The Role
As a Senior Scientist / Principal Scientist – Translational Medicine, you will serve as the translational medicine leader for the Genetic Medicines team at Alloy Therapeutics. In this role, you will drive all aspects of translational medicine for our oligonucleotide drug discovery programs, including design of preclinical pharmacology and toxicology studies. You will bridge rodent and NHP preclinical sciences by integrating DMPK, PK/PD, and biomarker data to build translational results that support candidate selection and advancement. A central focus of this role is leading and expanding Alloy's preclinical study capabilities, from study design through data interpretation. This role requires strong project management capabilities and the ability to operate with a high degree of autonomy in a fast-paced, dynamic start-up environment. Experience in oligonucleotide therapeutics is strongly preferred.
How You'll Drive Impact
- Lead: Serve as the translational science subject matter expert across oligonucleotide programs, with a strong emphasis on NHP study strategy and execution.
- Innovate: Develop and apply translational PK/PD frameworks and biomarker strategies tailored to oligonucleotide modalities, enabling data-driven program decisions.
- Deliver: Integrate preclinical DMPK, efficacy, and safety data across species into translational packages that support go/no-go decisions.
- Manage: Own translational workstream timelines, CRO/partner relationships, and cross-functional deliverables across multiple concurrent programs.
- Collaborate: Partner closely with Biology, Chemistry, and Safety/Tox teams, as well as external CROs and academic collaborators, to ensure translational strategies align with program goals.
- Lead translational projects and workstreams, overseeing study timelines, managing CRO deliverables, and proactively communicating risks and updates to stakeholders.
- Develop and lead translational PK/PD plans for oligonucleotide programs, integrating data across rodent and NHP species to support candidate selection and progression to clinical development.
- Own end-to-end NHP study execution: design studies, oversee sample collection and bioanalysis, and interpret data in the context of program objectives.
- Apply translational PK/PD modeling approaches to contextualize and compare PK, efficacy, and safety data across preclinical species.
- Oversee in vivo DMPK studies across multiple preclinical species, including NHP, encompassing pharmacokinetics, pharmacodynamics, toxicokinetics, biodistribution, and target-based and off-target effects.
- Lead toxicokinetic assessments, including exposure-response analysis and TK/PD evaluations, to contextualize safety findings across species.
- Integrate DMPK and biomarker data into coherent translational narratives that inform compound advancement decisions.
- Identify, develop, and qualify translational biomarkers (PK, PD, and safety) to support target engagement and proof-of-biology in NHP models.
- Prepare and present high-quality translational summaries and data packages for internal program reviews and external partnerships.
- Maintain comprehensive and accurate records using electronic lab notebooks (e.g., Benchling), ensuring meticulous documentation and data integrity.
- Mentor and provide scientific guidance to junior team members, fostering a culture of scientific rigor and innovation.
- Ph.D. in Pharmaceutical Sciences, Biochemistry, Molecular Biology, or a related discipline, with 6+ years of experience in biotech/pharma in a translational or DMPK role; or M.S. with 8+ years of relevant industry experience.
- Extensive hands-on experience designing and overseeing in vivo PK/PD studies in NHP is required.
- Familiarity with quantitative translational modeling approaches (e.g., allometric scaling, PBPK, PK/PD) is a plus.
- Proficiency in bioanalytical methods for oligonucleotide quantification (e.g., LC-MS/MS, hybridization-based assays).
- Experience with PK/PD data analysis tools (e.g., Phoenix WinNonlin, GraphPad Prism).
- Demonstrated project management skills, including the ability to manage multiple programs, external CROs, and cross-functional timelines simultaneously.
- Excellent written and verbal communication skills; ability to distill complex translational data into clear, decision-enabling summaries for diverse audiences.
- Proven ability to work independently and collaboratively in a fast-paced, start-up environment.
Preferred Qualifications
- Deep expertise in translational medicine as applied to oligonucleotide therapeutics (ASOs, siRNA, or related modalities) is strongly preferred.
- Familiarity with IND-enabling translational study design and regulatory expectations.
- Prior experience managing or mentoring scientists in a research setting.
Taking Care of Our People
Compensation
- Competitive base and equity compensation commensurate with level of experience and independence
- 401(k) company match
- Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
- Company-paid disability (STD, LTD) and life insurance
- Paid parental leave
- Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
- Unlimited PTO (paid time off) and flexible schedules
- Annual stipend for continuing education with commitment to your career through individualized professional development plan
- Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Pay Transparency
At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $145,000 - $170,000, with the final offer based on factors like your experience, skills, and alignment with our needs.
Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.
We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.
Apply for this position
Required*