Scientist, RNA Technology

  • South San Francisco, CA
  • Full Time
  • Experienced

Scientist, RNA Technology – South San Francisco, CA

APPLY HERE: https://alloytherapeutics.applytojob.com/apply

About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. We provide affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.  Founded in 2017 and privately funded by visionary investors, we are headquartered in Boston, MA with European labs in Cambridge, UK, and expanding to San Francisco Bay Area.  As a reflection of our relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

We believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms.  Alloy is expanding its ecosystem through the development of additional capabilities in adjacent biologic modalities.  The team and company are rapidly expanding; we are forming a new precision medicine group, generating RNA therapeutics in San Francisco Bay Area.  Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

 

Who You Are

We are seeking a hard-working and detail-oriented bench Scientist to build a new precision medicine platform. Our team needs someone with expertise in RNA molecular biology to work with and mentor. We are looking for people with expertise in developing and optimizing various molecular, biochemical, and cellular assays and who want to be on the ground floor to build this internal capability at Alloy Therapeutics. We hope to hear from you!

 

Principal Responsibilities

  • You will work in a team to drive towards milestone completion at hyperspeed
  • Conduct studies to understand optimal relationship between various drug delivery routes and dosing regimens, in terms of efficacy, biodistribution, and toxicity
  • Develop and evaluate new antisense oligonucleotide format/chemistry in terms of in vitro and in vivo efficacy, safety, biodistribution
  • Responsible for mechanistic investigation of factors affecting safety and translate into screening assay
  • You will work closely with senior leadership to communicate findings and implications and help drive the development this new platform
  • You will collaborate with the business development team to build data packages
  • Thrive and energized by a fast-paced start-up environment

 

Required Qualifications and Skills

  • Bachelor’s, Master’s, PhD Degree in Molecular Biology, Cell Biology, Biochemistry, or equivalent
  • BS with 7+ years, MS with 5+ years, PhD with 2+ years
  • Title will be aligned with experience
  • Hands on experience in dosing rodents in various routes such as IV, IP, ICV, SC and harvesting organ for biochemical analysis
  • Hands on experience in bio-distribution studies
  • Solid hand-on experience with commonly used techniques in cell, molecular biology, and biochemistry, such as cell culture, transfection, CRISPR KO, stable cell line selection, DNA/RNA/Protein extraction and analysis, cloning, qRT-PCR, real-time qPCR, subcellular fractionation, ELISA, Western blot, Northern blot, immunoprecipitation, immunofluorescence staining and microscopy imaging
  • Ability to conduct data analysis, interpret experimental results, and independently draw conclusions
  • Strategic thinking skills, with a high degree of independence, self-motivation, and attention to detail
  • Experience in planning and supervising the execution of experiments by scientific colleagues
  • Communication and soft skills with success in a diverse scientific environment
  • Ability to manage multiple assignments effectively in a quickly evolving environment
  • Ability to work well with external CROs and collaborators
  • Excellent organizational and time management skills
  • Rigorous scientific thinking and ability of problem solving
  • An independent sense of urgency, persistence, and integrity
  • Excellent oral and written communication skills
  • Ability to be productive and successful in a fast-paced, intense work environment
  • Ability to work both independently and within a team
     

Preferred Qualifications and Skills

  • Post PhD industry experience preferred
  • Exposure to nucleic acid modalities, including siRNA, antisense oligonucleotide (ASO), mRNA technology
  • Affinity to utilize new technologies and robotic automation for systematic consistency and efficiency

 

Benefits Include 

  • Competitive base salary based on the position and your experience level
  • Significant opportunities for advancement and mentorship inside Alloy, through our venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
  • Equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
  • Additional benefits including adoption support, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others
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