Principal Scientist, Bioanalytical

Waltham, MA
Full Time
Antibody Discovery Services
Experienced
The Company
We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, CH; and Athens, GA and 82VS portfolio companies in Boston, San Francisco, Dallas and Oklahoma City. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position with flexibility to work from home. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!

The Team
The Alloy Global Bioanalytics group provides bioanalytical support to all Alloy activities, including assay development, quality control and high-throughput characterization of antibodies, TCRs, TCR mimics and
other modalities.

The Role
As a Scientist / Senior Scientist, you will work with our Discovery Services team to support the discovery of antibody-based therapeutics. You will be using the very latest protein analytics tools and protocols with the ultimate goal of helping others to make better medicines. This role requires an enthusiasm for biochemical and biophysical characterization of antibodies, including bispecific and multispeicfic antibodies.

This role will report to our Senior Director of Global Bioanalytics with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy. This is you! 

How You’ll Drive Impact
  • Drive: Perform biochemical/biophysical characterization (e.g., protein purity, aggregation, charge variance), binding characterization (e.g., protein-protein interactions, cell binding, ligand inhibition assays), and/or developability assessment (e.g., thermostability, self-interaction, poly-reactivity)
  • Deliver: Achieve efficient execution of partner projects, maintain a balance between quality, timeline, and cost, thereby ensure successful project delivery. 
  • Support: Contribute and promote an inclusive and collaborative work environment
  • Innovate: Look for new ideas, assays, or tools for analytical evaluation of discovery outcome
  • Collaborate: Work closely with cross-functional teams spanning all Alloy locations.
Why We Value You
  • You have a Ph.D degree in a relevant scientific field (e.g. Biochemistry, Biotechnology, Biology), and have experience with antibody discovery and development
  • You have an in-depth knowledge of current state-of-the-art biochemical and biophysical characterization of antibodies, display a strong command of the fundamental principles of analytical chemistry 
  • You have experience with Flow Cytometry, SPR or BLI, SEC HPLC
  • You have experience with protein labeling including biotinylating and fluorophore labeling
  • You have a track record of troubleshooting instruments
  • You have excellent written and oral communication skills
  • You can multitask and accomplish goals under project and team timelines
  • You have an independent sense of urgency, persistence, and integrity
  • Attention to detail; Rigorous and innovative scientific thinking 
  • You have ELN and LIMS experience 
Desired Multipliers
  • You have experience with protein characterization by using LC-MS/MS
  • Ability to work across various US and international time zones 
  • Accommodate occasional travel as needed (<5%)

Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
  • Competitive base and equity compensation commensurate with level of experience and independence
  • 401(k) company match
Health & Family
  • Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
  • Company-paid disability (STD, LTD) and life insurance
  • Paid parental leave
  • Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
  • Unlimited PTO (paid time off) and flexible schedules
  • Annual stipend for continuing education with commitment to your career through individualized professional development plan
  • Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Diversity, Equity, and Inclusion
Here at Alloy, we democratize capabilities for discovering and developing therapeutic biologics. So, being diverse and inclusive isn’t just something we strive for, it is who we are, and part of what we do each and every single day. We want to ensure that as an employee, you feel Alloy is a place where, no matter who you are, you feel safe, included, and that you have the opportunity to bring your unique self to work.

Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [email protected]. We will make every effort to respond to your request for disability assistance as soon as possible.
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