Scientist / Associate Scientist, Protein Analytics

  • Waltham, MA
  • Full Time
  • Mid Level

Scientist / Associate Scientist, Protein Analytics – Waltham, MA


About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, Alloy democratizes access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. Alloy’s lead offering, the ATX-Gx™ platform, is a human therapeutic antibody discovery platform consisting of a growing suite of proprietary transgenic mice strains. Alloy is a leader in bispecific antibody discovery and engineering services, utilizing its proprietary ATX-CLC common light chain platform integrating novel transgenic mice and phage display. Alloy is headquartered in Boston, MA with labs in Cambridge, UK; Basel, CH; San Francisco, CA; and Athens, GA. As a reflection of Alloy’s relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. The team and company are rapidly expanding; successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.



About Scientist / Associate Scientist, Protein Analytics – Waltham, MA

Our Alloy Discovery Services group is looking for a Scientist or Associate Scientist to join our team in Waltham, Massachusetts. The position will report directly to our Senior Director of Analytics Characterization and work with our Discovery Services team to support the discovery of antibody-based therapeutics and the development of new platform technologies. You will be using the very latest protein analytics tools and protocols with the ultimate goal of helping others to make better medicines.

Principal Responsibilities

  • Support and run various antigen and antibody analytical techniques including:
    • Biochemical characterization (e.g., protein purity, aggregation, charge variance)
    • Binding characterization (e.g., protein-protein interactions, cell binding, ligand inhibition assays)
    • Developability assessment (e.g., self-interaction, poly-reactivity)
  • Be generous when others are needy, greedy or fearful


Required Qualifications and Skills

  • Ph.D. / M.S. / B.A in an appropriate scientific discipline (biochemistry, biophysics, cell biology or similar)
  • Experience with Flow Cytometry, SPR or BLI, or SEC HPLC
  • Demonstrated understanding of protein biochemical properties and protein-protein interactions
  • Attention to detail, rigorous and innovative scientific thinking and appropriate documentation, clear communication
  • An independent sense of urgency, persistence, and integrity


Preferred Qualifications and Skills

  • Experience in adapting manual processes to automation
  • Experience in high throughput antibody characterization assays
  • Familiarity with charge analysis (cIEF or CZE), size and purity analysis (CE-SDS, SEC HPLC, DSL), or Mass Spectrometry
  • Experience with protein labeling including biotinylating and fluorophore labeling
  • A track record of troubleshooting instruments
  • ELN and LIMS experience


Benefits Include 

  • Competitive base salary based on the position and your experience level
  • Significant opportunities for advancement inside Alloy, through our affiliated venture studio, 82VS, and across our partner companies
  • Equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
  • Additional benefits including adoption support, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others
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